
Platelet-Rich Fibrin (PRF) offers natural and effective solutions for various cosmetic procedures. One of the advantages of PRF is that it utilizes the patient's own blood, eliminating the risk of allergic reactions or rejection. Additionally, PRF offers a natural and long-lasting solution by harnessing the body's innate healing mechanisms.
At Nuance, PRF treatment offers exceptional natural results and clinical safety. While platelet-rich plasma (PRP) has been the industry standard for years, we utilize platelet-rich fibrin (PRF) because it contains more growth factors and more cells that remain active in the tissues for longer.
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Uses platelet-rich fibrin and human serum albumin from your own body, with no chemical additives or synthetic ingredients.

Provides immediate fullness like a filler while stimulating collagen production for long-term health.

Virtually zero risk of allergic reaction since the material is derived from the patient.

Effectively treats dark circles, marionette lines, and hair loss in a single regenerative treatment.

PRF ezGEL serves the purpose of skin rejuvenation and volumization. It comprises a 100% natural gel-like substance obtained from your own blood sample. Advanced technologies are employed to isolate the beneficial cells through a cooling and heating process, without the use of any chemical additives or modifications, resulting in the formation of the gel-like material. For scar revision, PRF can be applied topically or injected into the affected area to stimulate tissue regeneration, reduce scar visibility, and promote a more even skin texture. In hair restoration, PRF can be injected into the scalp to enhance hair growth, strengthen hair follicles, and improve hair density.
The PRF EZ Gel process begins with a small blood sample, similar to a routine lab test. This blood sample is then processed in a specialized centrifuge to separate the platelet-rich fibrin (PRF) from the red blood cells. To create the EZ Gel, a portion of your plasma undergoes a cooling and heating process to thicken the protein into a smooth, injectable gel. Once ready, the material is injected into the targeted areas using a fine needle or cannula. The entire procedure is unhurried, clinical, and centered on your comfort.

PRF can be utilized in various aesthetic treatments, including facial rejuvenation, scar revision, hair restoration, and skin rejuvenation. In facial rejuvenation, PRF can be injected into specific areas to enhance skin quality, reduce fine lines and wrinkles, and improve overall skin tone. It can also be combined with other cosmetic procedures like microneedling or laser therapy for enhanced results.
Hair Restoration
If you are struggling with thinning, weak, or brittle hair, PRF injections might be the solution you are looking for! Platelet-Rich Fibrin is one of the leading treatments for hair restoration. Hair restoration with PRP will likely take 3-4 treatments to see significant improvements in hair thinning. Each appointment is scheduled 4-6 weeks apart to allow the hair to grow and the PRF to take full effect.
Scar Treatment
Platelet-Rich Fibrin can be injected or microneedled into the skin to diminish the appearance of stretch marks and superficial and surgical scarring. Treating surgical scars with PRP is an excellent option that will likely require more than one appointment to achieve optimal results. Schedule a consultation with Nuance Aesthetics today to discuss your unique case!
Facial Injections
Platelet-Rich Fibrin can be strategically injected into areas of the face to stimulate collagen production, tighten lax skin, improve overall texture, and reduce the appearance of fine lines and wrinkles. Come to your appointment hydrated and ready to have a blood sample drawn. It addresses textural issues, volume loss (like nasolabial folds and marionette lines), and can also be used to treat dark circles and "tired" eyes by improving skin quality.

Because natural growth factors like PRF contain no chemical additives or anticoagulants, they are considered the purest and safest options available in modern aesthetics. Unlike traditional plasma treatments, the fibrin matrix in PRF provides a more robust, long-lasting release of growth factors, which act as powerful biostimulator, triggering the body to produce new collagen and essential proteins.
This process doesn't just provide a temporary "fill" for a wrinkle; it fundamentally improves the health and texture of your tissues. Most importantly, the natural gel material created through the EZ Gel process integrates seamlessly with your skin, ensuring a soft, smooth, and radiant finish that honors your unique facial character.

If you are looking for a 100% natural alternative to synthetic fillers, you are the perfect candidate for PRF (Platelet-Rich Fibrin) and EZGel. It is an ideal solution for patients with thin skin, under-eye hollows, or those who prefer a bio-filler derived from their own blood. Because it is autologous (sourced from your own tissue), there is virtually no risk of allergic reaction. PRF may not be suitable for patients with severe platelet disorders or those currently undergoing certain anticoagulant therapies.
There is no significant downtime after a PRF treatment, though you should expect mild swelling or a full sensation in the treated area for 24–48 hours as the gel integrates. To ensure the best results, we recommend staying hydrated and avoiding strenuous exercise or extreme heat (like saunas) for the first day. Since we use your own growth factors to trigger repair, avoiding anti-inflammatory medications like Ibuprofen for a few days post-treatment is encouraged to allow the natural inflammatory healing response to work its magic.

The beauty of EZGel is the two-fold transformation. You will see an immediate improvement in volume and smoothing of fine lines as the gel is injected. Over the following weeks, the PRF releases a high concentration of growth factors that stimulate your body to produce new collagen and elastin, improving the actual quality and thickness of your skin from the inside out.
While the immediate volume provides a beautiful refresh, the biological work continues for months. For the best results, we typically recommend a series of two treatments. Your rejuvenated skin quality can last a year or more, providing a refreshed look that is entirely, authentically you.

Working with PRF and EZGel requires a high level of clinical sophistication and timing. At Nuance, we utilize advanced centrifugation protocols to ensure we capture the highest concentration of regenerative cells possible. Our team combines this cutting-edge bio-technology with a master’s eye for facial anatomy, ensuring your bio-filler is placed precisely where it will provide the most natural lift and luminosity.
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The only pain involved is with micro needling or injection. We will use numbing cream to give you more comfort.
You will start seeing Natural Growth Factor treatment results about one to two months after the treatment. Collagen will continue to build over the next year.
Those who want to rejuvenate their skin naturally would be good candidates for Natural Growth Factor treatments. However, if you have a bleeding disorder and take blood thinners, you should avoid Natural Growth Factors.
Some providers prefer Natural Growth Factors since it does not have any anticoagulants and lasts longer.
You can treat any side effects using an old compress and over-the-counter pain medication. Always use skin protection after treatment.
Natural Growth Factors have side effects of redness, bruising and pain caused by the method used. In addition, you may experience puffiness when used under the eyes, but this only lasts four to five days.
Natural Growth Factor injections are totally different. They trigger collagen products and do not add volume to injected areas.
Depending on your unique needs and the application methods used, you may need a series of treatments followed by routine maintenance treatments. Treatments will be discussed at your consultation.
There is little to no downtime with Natural Growth Factors applied topically or via injections. However, you may experience redness, swelling, and bruising, and you should avoid direct sun exposure.
Avoid non-steroidal anti-inflammatory drugs for two weeks or more before treatments. Stay hydrated and don’t consume alcoholic beverages prior to treatment.